The Skyliner is a witness to design quality and visual finesse – just like every Neoplan coach since the fifties. The Skyliner's side view impresses with the new proportions of its window area, which visually extends the bodywork, lending it an air of aesthetically pleasing lightness. The double-decker coach is in no way bulky or cumbersome but makes a compact, manoeuvrable impression from every angle. Upper-deck side windows running well into the roof with the characteristic diamond cut of the transparent windows along the edge of the roof further underscore the Skyliner's exclusiveness. The three-axle vehicle's angled wheel arches emphasize its dynamic character. Thanks to clear and consistent lines and strikingly accentuated design elements, the designers were able to do without trendy decoration, which would have contradicted the objective of a Neoplan line with its timeless elegance.

The athletic rear end of the Skyliner is formed by the downward-tapering rear window, the chromed panel with Neoplan lettering (and integrated reversing camera), the distinctive cooling ribs and the curved rear lights made so well known by the Starliner and Cityliner. An elegantly formed bumper is the robust-looking completion of the rear end, while the spoiler-like end of the roof contributes to a reduction in drag.